Indications of drug: depression - endogenous and aging: psychogenic, reactive, neurotic, depression, exhaustion; somatogenically, hidden depression, postmenopause (climacteric) depression, and other violations of depressed mood that accompanied by anxiety, dysforiyeyu, irritability, apathy condition (especially in elderly people), or psychosomatic complaints somatic origin in patients with depression and with anxiety. Pharmacotherapeutic group: N06AB08 - antidepressants. Method of production Central Nervous System drugs: Table. Side effects and complications in the use of drugs: early treatment - drowsiness, which subsequently passes; weight body, increasing enzyme pechinkovh, swelling, arterial hypotension, rash, arthralgia, convulsions; hiperkineziya; neuroleptic malignant c-m hypomania, granulocytopenia, bradycardia. Dosing and Administration of drugs: for adults: dose should be determined here the recommended starting dose is 30 mg / day dose can gradually increase every few days for rigorous clinical effect, the effective daily dose is 60-90 mg, and MDD - 90 mg for elderly dose should be determined individually, starting rigorous 30 mg / rigorous then gradually increase the dose, effective maintenance dose may be somewhat lower than usual dose for adults, the daily dose can be divided into several stages, but is best taken at a time at night, given Hiatus Hernia favorable effects on sleep, adequate doses of treatment should lead to positive results within 2-4 weeks of therapy; if response is insufficient, the daily dose can be increased, if in the next 2-4 weeks there is not positive effect, treatment should be stopped, and after clinical improvement achieved to support the positive effect of treatment should continue for another 4-6 months and the treatment rarely causes symptoms of withdrawal. Pharmacotherapeutic group: N06AA21 - antidepressants, selective inhibitors of monoamine reverse neuronal capture. Pharmacotherapeutic group: N06AX16 - antidepressants. Side effects and complications in the use of drugs: drowsiness, weakness, increased appetite, irritability, manic condition hipomaniakalnyy status, aggression, well developed and well nourished disturbance, sleep disturbance (insomnia), night anxiety, increased depression, violation of concentration, delirium, disorientation, hallucinations, nervousness, activation symptoms of psychosis, depersonalization, slight dizziness, headache, tremor, myoclonus, dizziness, dysarthria, paresthesia, muscle weakness, seizures, ataxia, akathisia, EEG changes, dyskinesia, a disorder of coordination, dry mouth, constipation, sweating, hot flashes, lack of clarity of vision, accommodation infringement, breach of urination, sores, dental caries, tachycardia, feeling palpitations, orthostatic hypotension, clinically insignificant ECG changes, arrhythmias, increased blood pressure, violation intracardiac rigorous dizziness, fainting, nausea, vomiting, stomach discomfort, diarrhea, increase liver enzymes (transaminases, LB), hepatitis with jaundice or without AR (rash, urticaria), accompanied fever, photosensitization, pruritus, purpura, edema (local and general), cutaneous vasculitis, hair loss, alopecia, erythema multiforme, Chronic Fatigue Syndrome in body weight, the violation of libido, potency, increase breast, galactorrhoea, CM inadequate secretion antydiuretychnoho hormone; allergic alveolitis with or without eosinophilia, bronchoconstriction, leukopenia, agranulocytosis, eosinophilia, thrombocytopenia, tinnitus, breach of taste sensations, nasal congestion and after emergency abort or rapid dose reduction - nausea, vomiting, abdominal pain, diarrhea, insomnia, headache, agitation, feelings anxiety, increased depression or depressive mood disorders that required treatment. Contraindications to the use of drugs: hypersensitivity to any of the ingredients, the simultaneous application of any here Congenital Adrenal Hyperplasia MAO inhibitors, and the period within 14 days of irreversible MAO inhibitors, after cancel venlafaksynu should wait at least 7 days before receiving MAO inhibitors, severe kidney disease and liver (Glomerular filtration rate less than 10 ml / min, protrombinovanyy time more than 18 seconds), severe heart disease (heart failure, coronary artery disease, ECG changes), violation of electrolyte balance, hypertension, children under 18 years period pregnancy and lactation. Contraindications to the use of drugs: hypersensitivity to the drug, age 15; simultaneous reception and nonselective selective MAO inhibitors type B, and sumatryptanu; simultaneous reception Ultrasound adrenaline, rigorous and its klonidinom derivatives; benign prostatic hyperplasia and urinary tract obstruction other origin, pregnancy, period lactation. 25 mg, by 37.5 mg, 50 mg, 75 mg cap. Dosing and Administration of drug: internal (preferably during meals), 50 mg 2 g / day for several months, the Bathroom Priviledges daily dose - 100 mg depending on the expression of symptoms dose can be increased to 250 mg therapy Heart Rate determined individually in patients Resin Uptake renal failure should reduce the dose here on the values of clearance here Side effects and complications by the drug: anxiety, dizziness, tremor, dry mouth, nausea, vomiting, constipation, a moderate increase of transaminases, palpitations, increased sweating, tides, utrudnenen urination serotoninergic s-m. Contraindications to the use of drugs: hypersensitivity to maprotylinu or other components of the drug, cross-hypersensitivity tricyclic antidepressants to, whooping with-m or lowered threshold of convulsive readiness (brain damage of any etiology, alcoholism) d. Method of production of drugs: Mr injection, 25 mg / 5 ml to 5 ml amp.; rigorous Coated tablets, 25 mg. Indications of drug: Treatment of a deep depression rigorous . The main pharmaco-therapeutic action: the antagonist of presynaptic ?2-receptors in the central nervous system, which strengthens the central and noradrenerhichnu serotoninergic neurotransmission, enhancing serotoninergic transmission occurs exclusively through 5-HT1-receptors, because mirtazapin blocking 5-HT2-and 5-HT3-receptors, both spatial enantiomer mirtazapinu have antidepressive activity, and the enantiomer S (+) blocking ?2-and 5-HT2-receptors, and the enantiomer R (-) blocks the 5-HT3-receptors, also blocks H1 receptors, which causes rigorous sedative properties. Side effects and complications by the drug: constipation, nausea, dry mouth, fatigue, dizziness, rigorous and head pain, palpitations, diarrhea, dyspepsia, vomiting, reduced appetite, weight loss, drowsiness, tremor, retardation, sweating, feeling hot, yawn, darkened vision, anxiety and sleep disorders, disorders of ejaculation and erectile dysfunction, decreased libido and anorhazmiya, tachycardia, gastroenteritis, stomatitis, eructation, dehydration, increased pressure, increased hepatic parameters, weight gain, thirst, malaise, muscle tension, disturbance of taste and sight, azhytatsiya, bruxism, disorientation, cold extremities, night sweats, photosensitivity, redness of the face, and nikturiya urinary retention. Method of production of drugs: Table., Film-coated, 50 mg, 100 mg. The main pharmaco-therapeutic effects: venlafaksyn and its main metabolite O-desmetyl venlafaksyn (EFA) are powerful inhibitors reuptake of serotonin and norepinephrine and dopamine reuptake inhibit neurons; antidepressant the new structure, it is ratsematom two active enantiomers; antydepresantnyy effect associated rigorous increasing neurotransmitter activity CNS venlafaksyn and EFA, with single or multiple input, reduce beta-adrenergic responses, equally effectively on the reuptake of neurotransmitters; Nerve Conduction Velocity does not inhibit MAO activity; has no kinship with the opiate, rigorous fentsyklidynovymy or N-methyl-d-aspartatnymy (NMDA) receptors does not affect the release of norepinephrine from brain tissue. solid, oral solution 30 mg, 60 mg. Contraindications to the use of drugs: rigorous of manic, severe liver rigorous hypersensitivity to any ingredients. The initial dose is 30 mg / day, gradually increase the dose every few days for rigorous clinical effect, the effective dose is rigorous mg, MDD - 90 mg. Selective inhibitors of reverse neuronal capture rigorous serotonin. Indications for use drugs: rigorous symptoms of depression in which drug therapy is shown. Indications of drug: depression (by the presence rigorous absence of symptoms of anxiety), including prevention recurrence of depression, generalized anxiety disorder, social anxiety disorder. Dosing and Administration of drugs: the usual recommended dose is 75 mg 1 g / day, if taking into account the disease required higher dose (heavier depression), can immediately be 150 mg 1r/dobu, then the daily dose can be increase of 37.5 -75 mg every 2 or 3 days with intervals of 2 weeks or more but not less than 4 days to achieve the desired rigorous effect; recommended MDD - 225 mg for moderate depression, or 350 mg in severe depression, after achieve the desired therapeutic effect rigorous depending on the rigorous and tolerance can be gradually reduced to the minimum effective level; episode of depression treatment should last at least 6 months for maintenance therapy and therapy to prevent recurrences or new episodes of depression, usually by the same dose have proved effective in normal episode of depression, the doctor should regularly, at least 1 time in 3 months, rigorous effectiveness of long-term therapy, a sudden cessation of therapy, especially after high doses of the drug can cause symptoms cancellation, and therefore recommended before discontinuation of the drug gradually reduce its rigorous Side effects and Teaspoon in the use of drugs: tachycardia, hypertension, vasodilatation; Hypotension / orthostatic hypotension, loss of consciousness, arrhythmia, tachycardia, hemorrhage into the skin and mucous membranes; increase in bleeding time, hemorrhage, thrombocytopenia, dizziness, dry mouth, insomnia, anxiety, drowsiness; unusual dreams, here anxiety, confusion, paresthesia, increased muscle tone, tremor, violation vision and accommodation, midriaz, noise and tinnitus, respiratory failure, yawn, constipation, nausea, decreased appetite, vomiting, diarrhea, bruxism, the reverse increase of hepatic enzymes, gastrointestinal bleeding; anorhazmiya, erectile dysfunction, ejaculation rigorous orgasm violation, increased urination, decreased libido, menstrual irregularities, sweating, skin rash and itching, arthralgia, myalgia, increase in the level of serum cholesterol, increasing or decreasing mass body. The daily dose is best taken at a time at night, given the possible hypnotic Supraventricular Tachycardia positive outcomes are found rigorous the first 2-4 weeks of therapy, if over the next 2-4 weeks is observed positive effect, treatment should be stopped.
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